Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Built him out of meat cubes.
Beat depths without taking damage.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
You became Lord of the Flies.
Beat womb without taking damage.
New boss in the womb!
Isaac now holds the D6!
Donated 200 pennies to the shop.
You are the best!!
Unlocked Challenge #19.
New boss in the caves!
Unlocked another miniboss!
New boss in the basement!
New boss in the depths!
Beat Chest or Dark Room without taking damage.
They are waiting.
Beat caves without taking damage.
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #8.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Greed just got harder!
Unlocked a secret.
Unlocked Challenge #24.
Unlocked a new item
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with the Lost.
Beat everything in Hard Mode as every character.
Complete the Corpse with the Lost.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Get that song out of her head.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
They will charge you up... for a small fee.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Kill Hornfel before he escapes!
Make a new friend!
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Defeat all bosses in the Mines.
You are just like your father...
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.
Enter the Corpse...
Defeat all bosses in Downpour.
Defeat all bosses in the Mausoleum.
The other side is calling...
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Kill 10 Battery Bums.
Where could it lead to?
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.