Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
OMG!
New mode unlocked!
Unlocked Challenge #11.
Unlocked a new character.
Built him out of meat cubes.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
You are the best!!
Isaac now holds the D6!
Beat Chest or Dark Room without taking damage.
You became Lord of the Flies.
New boss in the womb!
Donated 600 pennies to the shop.
Unlocked Challenge #19.
Unlocked a new boss!
They are waiting.
New boss in the basement!
New boss in the caves!
Donated 200 pennies to the shop.
Unlocked Challenge #8.
Unlocked another miniboss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Unlocked Challenge #9.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
The game just got harder!
Beat caves without taking damage.
Donated 20 pennies to the shop.
Beat womb without taking damage.
Unlocked Challenge #6.
Beat depths without taking damage.
Beat basement without taking damage.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Unlocked Challenge #24.
Greed just got harder!
Unlocked Challenge #26.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Kill 10 Battery Bums.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
They will charge you up... for a small fee.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Defeat Baby Plum 10 times.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Defeat all bosses in the Mines.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Beat Greed mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in Downpour.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Make a new friend!
Complete the Chest with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Kids shouldn't believe in fortunes...
Beat Hard mode as Lazarus without losing a life
Kill Hornfel before he escapes!
Spend 40+ pennies in a single shop.
Complete ??? 3 times.