Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new character.
Unlocked Challenge #11.
Unlocked Challenge #4.
Unlocked even more bosses!
Unlocked a new co-player baby.
Unlocked new bosses!
Alt stage to the womb.
New boss in the basement!
You are the best!!
Beat Chest or Dark Room without taking damage.
Alt stage to the depths.
New boss in the womb!
New boss in the caves!
Alt stage to the caves.
Your future's past waits.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
New boss in the depths!
Isaac now holds the D6!
Unlocked Challenge #9.
Donated 600 pennies to the shop.
Beat basement without taking damage.
New mode unlocked!
The game just got harder!
Unlocked a new boss!
Unlocked Challenge #6.
Built him out of meat cubes.
Donated 200 pennies to the shop.
Unlocked another miniboss!
Donated 100 pennies to the shop.
Beat womb without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #8.
You became Lord of the Flies.
They are waiting.
Unlocked new enemies!
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked a new item
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked Challenge #29.
Unlocked Challenge #27.
Unlocked a hidden chapter.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Unlocked super special rocks.
Kill 10 Battery Bums.
Make a new friend!
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Bethany.
They will charge you up... for a small fee.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the final chapter with Eve.
Complete the final chapter with Samson.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the final chapter with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Azazel.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete ??? with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Isaac.
The other side is calling...
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Defeat Baby Plum 10 times.
Defeat all bosses in the Mines.
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Obtain 99 pennies. Then spend every single one of them.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.