Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
New mode unlocked!
Unlocked a new co-player baby.
Unlocked a new character.
Built him out of meat cubes.
Donated 600 pennies to the shop.
Unlocked Challenge #4.
Unlocked even more bosses!
You became Lord of the Flies.
New boss in the womb!
Unlocked new bosses!
Alt stage to the womb.
Beat Chest or Dark Room without taking damage.
You are the best!!
Unlocked new enemies!
Beat depths without taking damage.
Unlocked Challenge #11.
Unlocked Challenge #19.
Alt stage to the depths.
They are waiting.
Donated 200 pennies to the shop.
Unlocked Challenge #8.
Alt stage to the caves.
Beat womb without taking damage.
New boss in the basement!
Donated 100 pennies to the shop.
Unlocked a new boss!
Isaac now holds the D6!
New boss in the caves!
Unlocked Challenge #7.
Alt stage to the basement.
Your future's past waits.
New boss in the depths!
Unlocked Challenge #9.
Beat caves without taking damage.
Beat basement without taking damage.
The game just got harder!
Unlocked another miniboss!
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked a new starting item.
Unlocked...
Unlocked a secret.
Greed just got harder!
Nerd x 1000000
Unlocked Challenge #26.
Unlocked a new item
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked Challenge #29.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Make a new friend!
Beat everything in Hard Mode as every character.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greed mode with Bethany.
Complete the Corpse with the Lost.
Complete the final chapter with the Forgotten.
Complete the final chapter with the Lost.
Beat the Void with Bethany.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete ??? with Bethany.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with Bethany.
Defeat all bosses in the Mines.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with Judas.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with ???.
Complete the Corpse with Cain.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Complete the Dark Room with Bethany.
Defeat Mega Satan with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the final chapter with Bethany.
Complete the final chapter with Judas.
Defeat Mega Satan with Bethany.
Complete the final chapter with Magdalene.
Complete the final chapter with Cain.
Complete the final chapter with Apollyon.
Complete the final chapter with Eve.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the final chapter with ???.
Complete the final chapter with Samson.
Complete the final chapter with Azazel.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Complete the Corpse with Magdalene.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in Downpour.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Complete ??? 3 times.
Kids shouldn't believe in fortunes...
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.