Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
New mode unlocked!
OMG!
111% now stop playing!
Unlocked Challenge #11.
Donated 600 pennies to the shop.
Unlocked a new co-player baby.
You are the best!!
Isaac now holds the D6!
Unlocked a new boss!
Beat Chest or Dark Room without taking damage.
Donated 200 pennies to the shop.
They are waiting.
Built him out of meat cubes.
Donated 100 pennies to the shop.
Unlocked Challenge #19.
New boss in the basement!
New boss in the caves!
New boss in the depths!
New boss in the womb!
You became Lord of the Flies.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
The game just got harder!
Unlocked Challenge #9.
Beat womb without taking damage.
Unlocked another miniboss!
Unlocked Challenge #6.
Beat basement without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #8.
Destroy 100 rocks.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Greed just got harder!
Unlocked a secret.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Make a new friend!
Defeat Baby Plum 10 times.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with ???.
Complete the Corpse with Magdalene.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Isaac.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Obtain 99 pennies. Then spend every single one of them.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Get that song out of her head.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
They will charge you up... for a small fee.
Kill 10 Battery Bums.