Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Beat caves without taking damage.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked Challenge #11.
New boss in the womb!
You are the best!!
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Isaac now holds the D6!
Unlocked Challenge #19.
Unlocked a new boss!
They are waiting.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
New boss in the depths!
Beat womb without taking damage.
The game just got harder!
Built him out of meat cubes.
Unlocked Challenge #8.
Beat basement without taking damage.
New boss in the caves!
You became Lord of the Flies.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Unlocked another miniboss!
New boss in the basement!
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #24.
Unlocked a secret.
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked super special rocks.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with ???.
Complete the final chapter with Lilith.
Kill 10 Battery Bums.
Complete the final chapter with Magdalene.
Complete the Corpse with Judas.
They will charge you up... for a small fee.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Beat the Void with Bethany.
Complete the final chapter with Samson.
Complete the final chapter with Judas.
Complete the final chapter with Bethany.
Complete the final chapter with Keeper.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the final chapter with Apollyon.
Complete the final chapter with Isaac.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Defeat Baby Plum 10 times.
Defeat Mega Satan with Bethany.
Kids shouldn't believe in fortunes...
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Make a new friend!
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Defeat all bosses in the Mausoleum.
Get that song out of her head.
Kill Hornfel before he escapes!
Spend 40+ pennies in a single shop.
Complete ??? 3 times.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the Corpse with Magdalene.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.