Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Beat depths without taking damage.
Unlocked Challenge #4.
Built him out of meat cubes.
Unlocked Challenge #11.
Unlocked a new character.
Alt stage to the womb.
You are the best!!
Unlocked new enemies!
Beat womb without taking damage.
New mode unlocked!
Unlocked even more bosses!
You became Lord of the Flies.
New boss in the womb!
Unlocked Challenge #19.
Beat Chest or Dark Room without taking damage.
Unlocked new bosses!
Alt stage to the depths.
They are waiting.
New boss in the basement!
New boss in the caves!
Alt stage to the caves.
New boss in the depths!
Donated 600 pennies to the shop.
Isaac now holds the D6!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked Challenge #9.
The game just got harder!
Donated 200 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #8.
Unlocked Challenge #6.
Beat caves without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
OMG!
111% now stop playing!
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Unlocked Challenge #26.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked a new area.
Unlocked a new challenge.
Unlocked super special rocks.
Unlocked the power of RERUN.
Complete the Corpse with Keeper.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Eve.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Eden.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
The other side is calling...
Complete the Corpse with Eden.
Complete the Corpse with Isaac.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
They will charge you up... for a small fee.
Kids shouldn't believe in fortunes...
Complete ??? 3 times.
Beat Greed mode with Bethany.
Make a new friend!
Defeat Baby Plum 10 times.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.