Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Built him out of meat cubes.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Unlocked Challenge #11.
Unlocked a new boss!
You are the best!!
You became Lord of the Flies.
New boss in the caves!
Unlocked Challenge #19.
New boss in the basement!
Donated 200 pennies to the shop.
Isaac now holds the D6!
Beat womb without taking damage.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the depths!
They are waiting.
Unlocked Challenge #9.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 100 pennies to the shop.
The game just got harder!
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #6.
Unlocked another miniboss!
Beat basement without taking damage.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Unlocked Challenge #8.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Kids shouldn't believe in fortunes...
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
They will charge you up... for a small fee.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Lazarus.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Azazel.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Isaac.
Make a new friend!
Complete the Corpse with Eden.
Complete the final chapter with Judas.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Kill 10 Battery Bums.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Samson.
Complete the Corpse with Magdalene.
Complete the Corpse with Lazarus.
Get that song out of her head.
Complete the Corpse with Isaac.
Complete the Corpse with Samson.
Complete the Corpse with Judas.
Defeat Baby Plum 10 times.
Complete the final chapter with Magdalene.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Enter the Corpse...
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mausoleum.
Complete Boss Rush with Bethany.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.