Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked Challenge #11.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
You are the best!!
Unlocked Challenge #8.
Unlocked Challenge #19.
Beat caves without taking damage.
New boss in the womb!
Isaac now holds the D6!
Donated 600 pennies to the shop.
They are waiting.
Beat womb without taking damage.
Built him out of meat cubes.
Beat depths without taking damage.
Donated 200 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Unlocked a new boss!
Donated 100 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
You became Lord of the Flies.
New boss in the depths!
New boss in the caves!
Unlocked Challenge #6.
Unlocked another miniboss!
New boss in the basement!
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Unlocked Challenge #24.
Unlocked Challenge #26.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the Corpse with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Eve.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Lilith.
They will charge you up... for a small fee.
Complete the final chapter with ???.
Beat Greed mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with ???.
Complete the Corpse with Bethany.
Complete the Corpse with Apollyon.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Cain.
Complete the final chapter with Apollyon.
Complete the final chapter with Eve.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Lilith.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Defeat Baby Plum 10 times.
Kill 10 Battery Bums.
Complete the final chapter with Isaac.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Cain.
Defeat all bosses in Downpour.
The other side is calling...
Make a new friend!
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Beat Greed mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.