Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
New mode unlocked!
Built him out of meat cubes.
Unlocked a new character.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
Unlocked even more bosses!
Donated 600 pennies to the shop.
You are the best!!
Unlocked new enemies!
Unlocked new bosses!
Beat womb without taking damage.
Unlocked Challenge #19.
They are waiting.
New boss in the womb!
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
Isaac now holds the D6!
Alt stage to the womb.
Alt stage to the depths.
Alt stage to the basement.
Alt stage to the caves.
You became Lord of the Flies.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the caves!
New boss in the basement!
Unlocked Challenge #9.
New boss in the depths!
Unlocked a new boss!
Unlocked another miniboss!
Unlocked Challenge #8.
The game just got harder!
Unlocked Challenge #6.
Beat depths without taking damage.
Beat caves without taking damage.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
OMG!
111% now stop playing!
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Nerd x 1000000
Unlocked a new item
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Unlocked the power of RERUN.
Beat the game in Hard mode with Jacob and Esau.
Kill 10 Battery Bums.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Dark Room with Bethany.
Complete the final chapter with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Get that song out of her head.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Spend 40+ pennies in a single shop.
Complete the final chapter with Samson.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Samson.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with ???.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the final chapter with Azazel.
Complete the final chapter with Lilith.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Lilith.
Complete the Corpse with Isaac.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat Baby Plum 10 times.
Enter the Corpse...
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Make a new friend!
Beat the game in Hard mode with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.