Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat womb without taking damage.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
New boss in the womb!
You are the best!!
Unlocked Challenge #8.
Unlocked another miniboss!
Donated 600 pennies to the shop.
They are waiting.
New boss in the basement!
New boss in the caves!
You became Lord of the Flies.
Isaac now holds the D6!
New boss in the depths!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
The game just got harder!
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #6.
Beat basement without taking damage.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a secret.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Greed just got harder!
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Make a new friend!
Complete the Corpse with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Corpse with Azazel.
Complete the Corpse with Lilith.
Complete Sheol with Jacob and Esau.
Kill 10 Battery Bums.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Apollyon.
Complete the Corpse with Judas.
Complete the final chapter with Lazarus.
Complete the Corpse with Cain.
Complete the final chapter with Keeper.
Complete the final chapter with Eden.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with Lilith.
Defeat Baby Plum 10 times.
Complete the final chapter with ???.
Complete the final chapter with Magdalene.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Judas.
Complete the final chapter with Isaac.
Complete the final chapter with Cain.
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mines.
The other side is calling...
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Spend 40+ pennies in a single shop.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.