Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
New mode unlocked!
Built him out of meat cubes.
Unlocked even more bosses!
Isaac now holds the D6!
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
New boss in the womb!
Alt stage to the womb.
New boss in the basement!
Unlocked new bosses!
New boss in the caves!
Unlocked Challenge #4.
Unlocked Challenge #8.
Unlocked Challenge #11.
You became Lord of the Flies.
Alt stage to the depths.
Donated 600 pennies to the shop.
You are the best!!
Unlocked new enemies!
New boss in the depths!
Unlocked Challenge #19.
They are waiting.
Alt stage to the caves.
Beat depths without taking damage.
Unlocked Challenge #7.
Alt stage to the basement.
Your future's past waits.
Beat caves without taking damage.
Unlocked Challenge #9.
Unlocked a new boss!
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
Unlocked Challenge #6.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked a new item
Nerd x 1000000
Unlocked a new starting item.
Greed just got harder!
Unlocked a secret.
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #29.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked...
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Unlocked super special rocks.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Magdalene.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Defeat all bosses in the Mausoleum.
Defeat Mega Satan with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Cain.
Defeat all bosses in the Mines.
Complete the Corpse with Isaac.
Kill Hornfel before he escapes!
Complete the final chapter with Cain.
Defeat all bosses in Downpour.
Beat the game in Hard mode with Jacob and Esau.
Defeat Baby Plum 10 times.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Dark Room with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Magdalene.
Where could it lead to?
Enter the Corpse...
Complete ??? 3 times.
Complete the Chest with Bethany.
Complete Boss Rush with Bethany.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Complete Sheol with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Get that song out of her head.
Make a new friend!
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.