Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
Unlocked even more bosses!
Unlocked a new character.
New mode unlocked!
New boss in the womb!
Unlocked Challenge #4.
Unlocked new bosses!
You became Lord of the Flies.
Beat caves without taking damage.
Beat depths without taking damage.
Alt stage to the womb.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
New boss in the basement!
New boss in the caves!
New boss in the depths!
Isaac now holds the D6!
The game just got harder!
Your future's past waits.
Beat basement without taking damage.
Beat womb without taking damage.
Unlocked a new boss!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Unlocked another miniboss!
Built him out of meat cubes.
Donated 20 pennies to the shop.
Donated 100 pennies to the shop.
Donated 200 pennies to the shop.
Donated 600 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #6.
Unlocked Challenge #7.
Unlocked Challenge #8.
Unlocked Challenge #9.
Unlocked Challenge #10.
Unlocked Challenge #20.
You are the best!!
Unlocked new enemies!
Unlocked Challenge #19.
They are waiting.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked a new item
Unlocked...
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Complete the Corpse with Keeper.
Complete ??? with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the final chapter with Lilith.
Complete the final chapter with Samson.
Complete the final chapter with Keeper.
Complete the final chapter with Judas.
They will charge you up... for a small fee.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Dark Room with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Lazarus.
Make a new friend!
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Kill 10 Battery Bums.
Complete the final chapter with Azazel.
Complete the final chapter with Eve.
Complete the Corpse with Cain.
Complete the final chapter with Apollyon.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Defeat all bosses in the Mines.
The other side is calling...
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Complete Boss Rush with Bethany.
Complete the Chest with Bethany.
Defeat Mega Satan with Bethany.
Complete the Cathedral with Bethany.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Beat the game in Hard mode with Bethany.
Complete Sheol with Bethany.
Spend 40+ pennies in a single shop.
Complete ??? 3 times.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Chest with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.