Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Unlocked a new item.
New mode unlocked!
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Built him out of meat cubes.
Isaac now holds the D6!
Beat Chest or Dark Room without taking damage.
Beat caves without taking damage.
New boss in the womb!
You are the best!!
Beat depths without taking damage.
You became Lord of the Flies.
Unlocked Challenge #19.
They are waiting.
Unlocked Challenge #8.
Unlocked a new boss!
Donated 200 pennies to the shop.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the caves!
Beat womb without taking damage.
Unlocked Challenge #9.
New boss in the depths!
Donated 100 pennies to the shop.
New boss in the basement!
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked another miniboss!
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked...
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the final chapter with Azazel.
Complete the final chapter with Eden.
Complete the final chapter with the Lost.
Complete the final chapter with Lazarus.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Judas.
Kill 10 Battery Bums.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
They will charge you up... for a small fee.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Kids shouldn't believe in fortunes...
Complete the final chapter with Judas.
Complete the final chapter with Isaac.
Obtain 99 pennies. Then spend every single one of them.
Defeat Baby Plum 10 times.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Get that song out of her head.
Complete the Corpse with Isaac.
Beat the Void with Bethany.
Make a new friend!
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Complete ??? 3 times.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.