Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
Built him out of meat cubes.
Unlocked a new co-player baby.
Beat depths without taking damage.
Unlocked Challenge #11.
Donated 600 pennies to the shop.
New boss in the basement!
Unlocked Challenge #19.
Unlocked a new boss!
Beat Chest or Dark Room without taking damage.
New boss in the caves!
New boss in the womb!
Beat caves without taking damage.
You became Lord of the Flies.
You are the best!!
New boss in the depths!
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 200 pennies to the shop.
They are waiting.
Unlocked Challenge #9.
Unlocked another miniboss!
Donated 100 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
Unlocked Challenge #6.
Beat womb without taking damage.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked Challenge #8.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
111% now stop playing!
Unlocked a new item
Nerd x 1000000
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Defeat all bosses in Downpour.
Complete the final chapter with Isaac.
The other side is calling...
Make a new friend!
You are just like your father...
Enter the Corpse...
Complete the Corpse with Isaac.
Where could it lead to?
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Defeat Baby Plum 10 times.
Kids shouldn't believe in fortunes...
Beat the Void with Bethany.
Complete Sheol with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Beat the game in Hard mode with Bethany.
Spend 40+ pennies in a single shop.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Complete ??? with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.