Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked Challenge #11.
Unlocked a new co-player baby.
Isaac now holds the D6!
New boss in the womb!
You are the best!!
Beat womb without taking damage.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
They are waiting.
Donated 600 pennies to the shop.
Beat depths without taking damage.
You became Lord of the Flies.
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the basement!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
New boss in the depths!
Unlocked a new boss!
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Unlocked Challenge #8.
Unlocked another miniboss!
Donated 20 pennies to the shop.
Beat caves without taking damage.
Destroy 100 rocks.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Isaac.
Complete the Corpse with the Lost.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with the Lost.
Kill 10 Battery Bums.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Judas.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Cain.
Complete the Corpse with Isaac.
Beat everything in Hard mode with Bethany.
Complete the Dark Room with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the final chapter with Bethany.
The other side is calling...
Beat the Void with Bethany.
Complete ??? with Bethany.
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete Boss Rush with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.
Make a new friend!