Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked even more bosses!
Unlocked a new item.
Beat depths without taking damage.
Unlocked a new co-player baby.
Unlocked a new character.
Isaac now holds the D6!
New boss in the womb!
Unlocked new bosses!
New mode unlocked!
You are the best!!
Donated 600 pennies to the shop.
Alt stage to the womb.
Alt stage to the depths.
Alt stage to the caves.
Unlocked Challenge #11.
Unlocked Challenge #19.
Beat Chest or Dark Room without taking damage.
They are waiting.
Unlocked new enemies!
New boss in the caves!
New boss in the depths!
New boss in the basement!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Donated 200 pennies to the shop.
Unlocked Challenge #9.
Beat womb without taking damage.
You became Lord of the Flies.
The game just got harder!
Built him out of meat cubes.
Unlocked a new boss!
Unlocked another miniboss!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 100 pennies to the shop.
Beat caves without taking damage.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked Challenge #8.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
OMG!
111% now stop playing!
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Unlocked Challenge #27.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked a new challenge.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked super special rocks.
Complete the final chapter with Isaac.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Bethany.
Complete Boss Rush with Bethany.
Complete the Dark Room with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Azazel.
The other side is calling...
Defeat Mega Satan with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Kill 10 Battery Bums.
Complete the Cathedral with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
You are just like your father...
Complete the Corpse with the Lost.
Where could it lead to?
Defeat all bosses in the Mines.
Defeat Baby Plum 10 times.
Defeat all bosses in the Mausoleum.
Kids shouldn't believe in fortunes...
Defeat all bosses in Downpour.
Enter the Corpse...
Spend 40+ pennies in a single shop.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Kill Hornfel before he escapes!
Complete ??? 3 times.
Get that song out of her head.
Make a new friend!
Complete the Dark Room with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Corpse with Isaac.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Obtain 99 pennies. Then spend every single one of them.