Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Unlocked Challenge #11.
Built him out of meat cubes.
Beat depths without taking damage.
Donated 600 pennies to the shop.
Isaac now holds the D6!
Beat Chest or Dark Room without taking damage.
New boss in the womb!
You became Lord of the Flies.
You are the best!!
Beat womb without taking damage.
Unlocked Challenge #19.
They are waiting.
Unlocked a new boss!
Unlocked another miniboss!
New boss in the basement!
New boss in the caves!
New boss in the depths!
Beat caves without taking damage.
Donated 200 pennies to the shop.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked Challenge #8.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #24.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with ???.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with Apollyon.
Complete the Corpse with Azazel.
Complete the Corpse with Eden.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Kill Hornfel before he escapes!
Get that song out of her head.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Judas.
Complete the final chapter with the Lost.
Complete the final chapter with the Forgotten.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with Lilith.
Complete the final chapter with Apollyon.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Isaac.
Complete the final chapter with ???.
Complete the final chapter with Eve.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Keeper.
Defeat Baby Plum 10 times.
Make a new friend!
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Kids shouldn't believe in fortunes...
Complete the final chapter with Azazel.
The other side is calling...
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat all bosses in the Mines.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Spend 40+ pennies in a single shop.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with the Forgotten.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.