Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Built him out of meat cubes.
Unlocked a new co-player baby.
Unlocked a new character.
New mode unlocked!
Donated 600 pennies to the shop.
Unlocked Challenge #8.
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked another miniboss!
You are the best!!
Unlocked new enemies!
Unlocked even more bosses!
Isaac now holds the D6!
Alt stage to the womb.
New boss in the womb!
Unlocked new bosses!
Beat Chest or Dark Room without taking damage.
They are waiting.
Beat caves without taking damage.
New boss in the basement!
New boss in the caves!
Alt stage to the depths.
Beat basement without taking damage.
Alt stage to the caves.
You became Lord of the Flies.
Donated 200 pennies to the shop.
Alt stage to the basement.
Unlocked a new boss!
New boss in the depths!
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #9.
Beat depths without taking damage.
Donated 100 pennies to the shop.
Beat womb without taking damage.
The game just got harder!
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Destroy 100 rocks.
The horsemen are loose.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat Greed mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Keeper.
Get that song out of her head.
Complete the final chapter with Keeper.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Bethany.
Kids shouldn't believe in fortunes...
Make a new friend!
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mausoleum.
Defeat Baby Plum 10 times.
Complete the final chapter with Isaac.
The other side is calling...
Defeat all bosses in the Mines.
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Mega Satan with Bethany.
Complete Boss Rush with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.