Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Unlocked Challenge #11.
Built him out of meat cubes.
Donated 600 pennies to the shop.
Beat womb without taking damage.
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
You are the best!!
Isaac now holds the D6!
New boss in the womb!
Unlocked Challenge #19.
Donated 200 pennies to the shop.
They are waiting.
Unlocked a new boss!
Unlocked Challenge #8.
New boss in the caves!
You became Lord of the Flies.
New boss in the basement!
New boss in the depths!
Unlocked another miniboss!
Beat caves without taking damage.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Greed just got harder!
Unlocked a secret.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat everything in Hard Mode as every character.
Beat Greed mode with Bethany.
Beat the Void with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete Boss Rush with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Corpse with Keeper.
Make a new friend!
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the final chapter with Eden.
Kids shouldn't believe in fortunes...
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Kill 10 Battery Bums.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Get that song out of her head.
Complete the Corpse with ???.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with Cain.
Defeat Baby Plum 10 times.
Complete the final chapter with Cain.
Complete the final chapter with ???.
Complete the Corpse with Magdalene.
Defeat all bosses in the Mines.
Complete the final chapter with Lazarus.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Obtain 99 pennies. Then spend every single one of them.
The other side is calling...
Spend 40+ pennies in a single shop.
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.