Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Unlocked a new character.
Unlocked even more bosses!
New boss in the womb!
Built him out of meat cubes.
You are the best!!
Unlocked new enemies!
Unlocked Challenge #11.
You became Lord of the Flies.
Isaac now holds the D6!
Alt stage to the womb.
Unlocked new bosses!
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Alt stage to the depths.
Unlocked a new boss!
Unlocked Challenge #19.
They are waiting.
Alt stage to the caves.
Alt stage to the basement.
Unlocked Challenge #8.
New boss in the depths!
Unlocked another miniboss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #20.
Unlocked Challenge #9.
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the basement!
The game just got harder!
Beat basement without taking damage.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Beat depths without taking damage.
Beat caves without taking damage.
Beat womb without taking damage.
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
Unlocked a new starting item.
Unlocked a secret.
Nerd x 1000000
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked a new challenge.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked super special rocks.
Complete the final chapter with Azazel.
Complete the final chapter with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with the Forgotten.
Defeat all bosses in the Mausoleum.
Complete the Corpse with Isaac.
Complete the Corpse with Magdalene.
Beat Greed mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat Greed mode with Bethany.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete the Dark Room with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Make a new friend!
The other side is calling...
Beat the game in Hard mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Azazel.
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in Downpour.
Complete ??? 3 times.
Defeat Baby Plum 10 times.
Complete ??? with Bethany.
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Kids shouldn't believe in fortunes...
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Complete Boss Rush with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete Boss Rush with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Isaac.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.