Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
Unlocked Challenge #11.
Unlocked a new co-player baby.
New mode unlocked!
Unlocked a new character.
Built him out of meat cubes.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Beat Chest or Dark Room without taking damage.
Isaac now holds the D6!
Beat caves without taking damage.
New boss in the womb!
Unlocked Challenge #19.
Beat womb without taking damage.
You are the best!!
They are waiting.
Donated 600 pennies to the shop.
You became Lord of the Flies.
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
Beat depths without taking damage.
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
New boss in the depths!
New boss in the caves!
New boss in the basement!
The game just got harder!
Unlocked another miniboss!
Unlocked Challenge #6.
Beat basement without taking damage.
Unlocked Challenge #8.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
111% now stop playing!
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked...
Unlocked a new area.
Unlocked a new challenge.
Unlocked super special rocks.
Unlocked the power of RERUN.
They will charge you up... for a small fee.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with the Forgotten.
Get that song out of her head.
Kill 10 Battery Bums.
Beat Greedier mode with Bethany.
Complete the final chapter with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the final chapter with the Forgotten.
Make a new friend!
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Lazarus.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the Corpse with Apollyon.
Complete the Corpse with Lilith.
Complete the final chapter with Eve.
Complete the Corpse with Cain.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Complete the Corpse with Magdalene.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Lilith.
Complete the final chapter with Apollyon.
Complete the Corpse with Lazarus.
Complete the final chapter with Magdalene.
Complete the Corpse with Samson.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the Corpse with Isaac.
Complete the Corpse with Eden.
Kids shouldn't believe in fortunes...
Complete the final chapter with Eden.
Complete the final chapter with Samson.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
The other side is calling...
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Kill Hornfel before he escapes!
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.