Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked Challenge #11.
Unlocked a new co-player baby.
Built him out of meat cubes.
New mode unlocked!
Unlocked even more bosses!
New boss in the womb!
Unlocked a new character.
Unlocked new bosses!
Unlocked Challenge #4.
Alt stage to the womb.
You are the best!!
Isaac now holds the D6!
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Alt stage to the depths.
Beat basement without taking damage.
They are waiting.
Unlocked new enemies!
Unlocked Challenge #19.
Beat caves without taking damage.
Unlocked Challenge #8.
Alt stage to the caves.
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
New boss in the caves!
Beat womb without taking damage.
Unlocked Challenge #9.
Unlocked a new boss!
The game just got harder!
Unlocked Challenge #6.
New boss in the basement!
Donated 200 pennies to the shop.
Unlocked another miniboss!
Donated 100 pennies to the shop.
You became Lord of the Flies.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked super special rocks.
Unlocked a new area.
Complete the Corpse with Lilith.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Azazel.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with the Lost.
Complete the final chapter with Bethany.
Beat the Void with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Eden.
They will charge you up... for a small fee.
Make a new friend!
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the final chapter with Azazel.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Apollyon.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Complete the final chapter with Magdalene.
The other side is calling...
You are just like your father...
Complete the Corpse with Samson.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Beat Greed mode with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Cathedral with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.