Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked Challenge #11.
Built him out of meat cubes.
New mode unlocked!
Unlocked a new character.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Donated 600 pennies to the shop.
Beat depths without taking damage.
You became Lord of the Flies.
New boss in the womb!
Beat womb without taking damage.
Unlocked Challenge #19.
You are the best!!
Beat Chest or Dark Room without taking damage.
They are waiting.
Isaac now holds the D6!
Unlocked a new boss!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Beat caves without taking damage.
Unlocked Challenge #9.
Unlocked Challenge #8.
New boss in the depths!
New boss in the caves!
Donated 200 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
New boss in the basement!
Donated 100 pennies to the shop.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Unlocked another miniboss!
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with Magdalene.
Complete the Corpse with ???.
Complete the final chapter with the Forgotten.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Jacob and Esau.
Complete ??? with Bethany.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the final chapter with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Magdalene.
Complete the Corpse with Eden.
Complete the Corpse with Keeper.
Complete the final chapter with Azazel.
Complete the final chapter with Judas.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Apollyon.
Complete the final chapter with Eve.
Beat Greedier mode with Bethany.
Complete the final chapter with Keeper.
Complete the Corpse with Azazel.
Complete the Corpse with Lilith.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Judas.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Lilith.
Complete the final chapter with Isaac.
Complete the Corpse with Lazarus.
Complete the final chapter with Apollyon.
Complete the final chapter with Cain.
Complete the final chapter with Samson.
Complete the Corpse with Cain.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
The other side is calling...
Complete the Corpse with Samson.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Make a new friend!
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Kids shouldn't believe in fortunes...
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
They will charge you up... for a small fee.
Kill 10 Battery Bums.