Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked new bosses!
Beat depths without taking damage.
Unlocked a new character.
New mode unlocked!
Unlocked Challenge #11.
New boss in the womb!
Donated 600 pennies to the shop.
Beat caves without taking damage.
You became Lord of the Flies.
Alt stage to the womb.
You are the best!!
Isaac now holds the D6!
Beat womb without taking damage.
Alt stage to the depths.
Unlocked Challenge #19.
Unlocked a new boss!
Built him out of meat cubes.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
New boss in the caves!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the basement!
New boss in the depths!
They are waiting.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
The game just got harder!
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #8.
Destroy 100 rocks.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with Lilith.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete the final chapter with Lilith.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Make a new friend!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Kill 10 Battery Bums.
Beat Greed mode with Bethany.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.