Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat caves without taking damage.
New mode unlocked!
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked Challenge #11.
Donated 600 pennies to the shop.
Beat womb without taking damage.
New boss in the womb!
Isaac now holds the D6!
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
You are the best!!
You became Lord of the Flies.
New boss in the caves!
Unlocked Challenge #19.
New boss in the depths!
Donated 200 pennies to the shop.
Unlocked a new boss!
They are waiting.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Beat basement without taking damage.
New boss in the basement!
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #8.
Unlocked another miniboss!
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Destroy 100 rocks.
Unlocked Challenge #20.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #24.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Beat everything in Hard Mode as every character.
Complete the Corpse with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Lilith.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the final chapter with ???.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Isaac.
Complete Sheol with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Apollyon.
Complete the final chapter with Eve.
Complete the final chapter with Judas.
Complete the final chapter with Lilith.
Complete the Corpse with Eden.
Complete the final chapter with Cain.
Complete the Corpse with Keeper.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Keeper.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Kill 10 Battery Bums.
The other side is calling...
You are just like your father...
Complete the Corpse with Cain.
Where could it lead to?
They will charge you up... for a small fee.
Make a new friend!
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.
Defeat all bosses in the Mines.
Beat the game in Hard mode with Bethany.
Complete the Cathedral with Bethany.
Complete the Chest with Bethany.
Defeat Mega Satan with Bethany.
Kill Hornfel before he escapes!
Obtain 99 pennies. Then spend every single one of them.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Defeat all bosses in Downpour.
Complete ??? 3 times.