Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked even more bosses!
Unlocked a new character.
Unlocked new bosses!
Unlocked new enemies!
Alt stage to the womb.
Alt stage to the depths.
Alt stage to the caves.
New mode unlocked!
Alt stage to the basement.
New boss in the basement!
New boss in the caves!
New boss in the depths!
Isaac now holds the D6!
The game just got harder!
Your future's past waits.
Beat caves without taking damage.
Beat depths without taking damage.
Beat womb without taking damage.
You are the best!!
Unlocked a new boss!
New boss in the womb!
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
Donated 200 pennies to the shop.
Donated 600 pennies to the shop.
They are waiting.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked a new co-player baby.
You became Lord of the Flies.
Unlocked Challenge #6.
Built him out of meat cubes.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #8.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Beat basement without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a secret.
Unlocked a new starting item.
Unlocked...
Nerd x 1000000
Greed just got harder!
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Unlocked the power of RERUN.
Complete the final chapter with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Keeper.
Beat Greedier mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Lazarus.
Complete the final chapter with Magdalene.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with Eden.
Complete the final chapter with Lilith.
Complete Boss Rush with Jacob and Esau.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Eden.
Beat Greed mode with Bethany.
Enter the Corpse...
Defeat all bosses in Downpour.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Get that song out of her head.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Kill 10 Battery Bums.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Make a new friend!
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Bethany.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.