Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Built him out of meat cubes.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Beat depths without taking damage.
Unlocked Challenge #11.
Isaac now holds the D6!
Donated 600 pennies to the shop.
Unlocked Challenge #19.
New boss in the womb!
You are the best!!
They are waiting.
New boss in the caves!
New boss in the depths!
Beat caves without taking damage.
You became Lord of the Flies.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the basement!
Unlocked a new boss!
Unlocked Challenge #8.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked another miniboss!
Unlocked Challenge #6.
Beat basement without taking damage.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #26.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Complete the final chapter with Azazel.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with the Lost.
Complete the Corpse with Apollyon.
Complete the Corpse with Isaac.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Keeper.
Complete Sheol with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Eden.
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Make a new friend!
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Beat Greed mode with Bethany.
Complete the final chapter with Lazarus.
Kids shouldn't believe in fortunes...
Complete the final chapter with Isaac.
Kill 10 Battery Bums.
Complete the final chapter with Magdalene.
Complete the final chapter with Eden.
Complete the final chapter with Cain.
Get that song out of her head.
Complete the final chapter with Samson.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Kill Hornfel before he escapes!
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mines.
Complete ??? 3 times.
Complete Boss Rush with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.