Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Built him out of meat cubes.
Unlocked a new co-player baby.
Beat caves without taking damage.
Beat Chest or Dark Room without taking damage.
Beat basement without taking damage.
Unlocked Challenge #11.
New boss in the womb!
Unlocked a new boss!
New boss in the basement!
You are the best!!
New boss in the caves!
You became Lord of the Flies.
Unlocked Challenge #19.
Unlocked Challenge #8.
They are waiting.
Donated 600 pennies to the shop.
New boss in the depths!
Isaac now holds the D6!
Beat depths without taking damage.
Donated 200 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat womb without taking damage.
Unlocked Challenge #9.
Unlocked another miniboss!
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat the game in Hard mode with Jacob and Esau.
Beat the game in Hard mode with Bethany.
Complete ??? with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Beat the Void with Bethany.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
They will charge you up... for a small fee.
Complete the Corpse with the Lost.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Lilith.
Complete the Corpse with the Forgotten.
Complete the Corpse with Lazarus.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Samson.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Eden.
Complete the Corpse with Azazel.
Complete the Corpse with Eve.
Kill Hornfel before he escapes!
Complete the Corpse with ???.
Make a new friend!
Complete the Corpse with Judas.
Defeat all bosses in Downpour.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Defeat all bosses in the Mausoleum.
Defeat Mega Satan with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with the Lost.
Complete the final chapter with Jacob and Esau.
Kill 10 Battery Bums.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Defeat Baby Plum 10 times.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Spend 40+ pennies in a single shop.
Complete the final chapter with Eden.
The other side is calling...
You are just like your father...
Complete the Corpse with Cain.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mines.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Complete ??? 3 times.
Beat everything in Hard mode with Bethany.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.