Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Beat womb without taking damage.
Unlocked Challenge #11.
Unlocked a new character.
Isaac now holds the D6!
Beat depths without taking damage.
Built him out of meat cubes.
Unlocked a new co-player baby.
Unlocked even more bosses!
Beat caves without taking damage.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
Unlocked new bosses!
New boss in the womb!
You are the best!!
Unlocked new enemies!
They are waiting.
You became Lord of the Flies.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Donated 600 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked a new boss!
Unlocked Challenge #9.
New boss in the depths!
The game just got harder!
New boss in the caves!
New boss in the basement!
Donated 200 pennies to the shop.
Unlocked Challenge #6.
Unlocked another miniboss!
Unlocked Challenge #8.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Beat basement without taking damage.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
OMG!
111% now stop playing!
New mode unlocked!
Nerd x 1000000
Unlocked a new item
Greed just got harder!
Unlocked a new starting item.
Unlocked Challenge #26.
Unlocked a secret.
Unlocked Challenge #27.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a hidden chapter.
Unlocked...
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Unlocked the power of RERUN.
Complete the final chapter with ???.
Complete the Cathedral with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Isaac.
Complete the final chapter with Lazarus.
Complete the final chapter with Eve.
Complete the final chapter with Cain.
Complete the final chapter with Eden.
Complete the final chapter with Judas.
Complete the final chapter with Isaac.
Complete the final chapter with Magdalene.
Complete the final chapter with Lilith.
Complete the final chapter with Samson.
Complete Boss Rush with Bethany.
Complete the final chapter with Azazel.
Kids shouldn't believe in fortunes...
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Get that song out of her head.
Enter the Corpse...
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Make a new friend!
Obtain 99 pennies. Then spend every single one of them.
Beat the game in Hard mode with Bethany.
Beat Greed mode with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Kill Hornfel before he escapes!
Beat everything in Hard Mode as every character.