Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
Built him out of meat cubes.
Unlocked Challenge #11.
Donated 600 pennies to the shop.
OMG!
You became Lord of the Flies.
New boss in the womb!
Beat womb without taking damage.
Unlocked a new boss!
Unlocked Challenge #19.
Isaac now holds the D6!
You are the best!!
Beat depths without taking damage.
They are waiting.
Donated 200 pennies to the shop.
New boss in the depths!
New boss in the caves!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the basement!
Beat caves without taking damage.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #8.
Unlocked Challenge #6.
Unlocked another miniboss!
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard Mode as every character.
Complete the final chapter with the Lost.
Complete the Corpse with ???.
Complete the Corpse with the Forgotten.
They will charge you up... for a small fee.
Complete the final chapter with the Forgotten.
Beat everything in Hard mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the Corpse with the Lost.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Azazel.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Magdalene.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Complete the Corpse with Isaac.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Eden.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Apollyon.
Complete the final chapter with ???.
Complete the final chapter with Magdalene.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with Isaac.
Complete the final chapter with Eden.
Make a new friend!
Get that song out of her head.
Complete the Corpse with Azazel.
The other side is calling...
Kids shouldn't believe in fortunes...
You are just like your father...
Complete the Corpse with Cain.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Kill 10 Battery Bums.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.