Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Built him out of meat cubes.
New mode unlocked!
Unlocked Challenge #11.
Unlocked a new character.
Beat depths without taking damage.
Beat womb without taking damage.
Unlocked even more bosses!
Beat Chest or Dark Room without taking damage.
Alt stage to the womb.
New boss in the womb!
Unlocked new bosses!
You are the best!!
Isaac now holds the D6!
Beat caves without taking damage.
Alt stage to the depths.
Alt stage to the caves.
New boss in the caves!
Unlocked Challenge #19.
New boss in the basement!
Alt stage to the basement.
Unlocked a new boss!
Donated 200 pennies to the shop.
New boss in the depths!
You became Lord of the Flies.
They are waiting.
Unlocked new enemies!
Donated 100 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
The game just got harder!
Unlocked another miniboss!
Unlocked Challenge #6.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Unlocked Challenge #8.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Get that song out of her head.
Make a new friend!
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with the Lost.
Complete the final chapter with Keeper.
Complete the final chapter with the Forgotten.
Complete the final chapter with ???.
Complete the final chapter with Lilith.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with Apollyon.
Complete the final chapter with Lazarus.
Complete the final chapter with Magdalene.
Complete the final chapter with Eve.
Complete the final chapter with Samson.
Complete the final chapter with Azazel.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Complete the final chapter with Eden.
The other side is calling...
Complete the Corpse with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with the Lost.
Defeat Baby Plum 10 times.
Complete the Corpse with Keeper.
Complete the Corpse with ???.
Complete the Corpse with Lazarus.
Complete the Corpse with Azazel.
Complete the Corpse with Magdalene.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with Judas.
Complete the Corpse with Isaac.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Cain.
Beat Greedier mode with Bethany.
Defeat all bosses in the Mines.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete ??? with Bethany.
Beat the Void with Bethany.
Complete the Chest with Bethany.
Beat Greed mode with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Kids shouldn't believe in fortunes...
Complete the Cathedral with Bethany.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
Complete the Corpse with Eden.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Spend 40+ pennies in a single shop.
Complete ??? 3 times.