Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
Donated 600 pennies to the shop.
New mode unlocked!
Unlocked even more bosses!
New boss in the womb!
Alt stage to the womb.
New boss in the basement!
Unlocked Challenge #11.
Unlocked new bosses!
Isaac now holds the D6!
You are the best!!
Beat caves without taking damage.
New boss in the caves!
Alt stage to the depths.
Alt stage to the caves.
New boss in the depths!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Donated 200 pennies to the shop.
Built him out of meat cubes.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #9.
You became Lord of the Flies.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked another miniboss!
Unlocked Challenge #6.
Beat basement without taking damage.
Beat Chest or Dark Room without taking damage.
They are waiting.
Unlocked new enemies!
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked Challenge #8.
Beat womb without taking damage.
Beat depths without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Unlocked Challenge #27.
Unlocked Challenge #24.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #26.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked super special rocks.
Unlocked a new area.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with the Lost.
Complete the final chapter with Samson.
Complete the final chapter with Cain.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Make a new friend!
Complete the final chapter with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Lilith.
Complete the final chapter with Lazarus.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Complete the final chapter with Keeper.
Complete the final chapter with Eve.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat the Void with Bethany.
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with the Forgotten.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the Corpse with Lilith.
Kill 10 Battery Bums.
Complete the Corpse with the Lost.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the Corpse with Magdalene.
Complete the final chapter with Azazel.
They will charge you up... for a small fee.
Complete the Corpse with Lazarus.
Complete the final chapter with Eden.
Kids shouldn't believe in fortunes...
Complete the Corpse with Cain.
Complete the final chapter with Isaac.
Obtain 99 pennies. Then spend every single one of them.
Complete Sheol with Bethany.
The other side is calling...
Complete the Corpse with Eden.
Complete the Corpse with Isaac.
Defeat Baby Plum 10 times.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Enter the Corpse...
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mines.
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Get that song out of her head.
Defeat all bosses in Downpour.
Spend 40+ pennies in a single shop.
Complete ??? 3 times.