Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
Isaac now holds the D6!
Unlocked even more bosses!
Alt stage to the womb.
New boss in the basement!
New boss in the womb!
Donated 600 pennies to the shop.
Unlocked new bosses!
Unlocked a new boss!
Beat womb without taking damage.
New boss in the caves!
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
New mode unlocked!
Built him out of meat cubes.
Alt stage to the depths.
Unlocked Challenge #19.
You are the best!!
Alt stage to the caves.
They are waiting.
Unlocked new enemies!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Donated 200 pennies to the shop.
New boss in the depths!
Beat depths without taking damage.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
The game just got harder!
You became Lord of the Flies.
Unlocked another miniboss!
Unlocked Challenge #6.
Unlocked Challenge #8.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Beat caves without taking damage.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked Challenge #26.
Unlocked a hidden chapter.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new challenge.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked super special rocks.
Kill 10 Battery Bums.
They will charge you up... for a small fee.
Defeat Baby Plum 10 times.
Make a new friend!
Get that song out of her head.
Kids shouldn't believe in fortunes...
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat Greed mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the Void with Bethany.
Complete the Cathedral with Bethany.
Complete the Chest with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
The other side is calling...
Defeat all bosses in the Mausoleum.
Complete the Corpse with Magdalene.
Defeat all bosses in Downpour.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Isaac.
Defeat all bosses in the Mines.
Defeat Mega Satan with Bethany.
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Beat the game in Hard mode with Bethany.
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Complete ??? 3 times.