Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Beat depths without taking damage.
Beat womb without taking damage.
Unlocked a new character.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
New mode unlocked!
Beat caves without taking damage.
Unlocked Challenge #11.
Unlocked Challenge #4.
Unlocked even more bosses!
Isaac now holds the D6!
Unlocked new bosses!
New boss in the womb!
Alt stage to the womb.
Donated 600 pennies to the shop.
You are the best!!
Alt stage to the depths.
Alt stage to the caves.
They are waiting.
Unlocked new enemies!
Unlocked Challenge #19.
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
Unlocked a new boss!
The game just got harder!
New boss in the depths!
You became Lord of the Flies.
New boss in the caves!
Unlocked Challenge #5.
Unlocked Challenge #10.
New boss in the basement!
Unlocked Challenge #8.
Unlocked Challenge #6.
Unlocked another miniboss!
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked super special rocks.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Get that song out of her head.
Complete the final chapter with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Lazarus.
Complete the Corpse with Eve.
Complete the Corpse with Judas.
Complete the final chapter with Eve.
Complete the final chapter with Samson.
Complete the final chapter with Judas.
Complete the Corpse with Samson.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the final chapter with Lazarus.
Complete the final chapter with the Lost.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Dark Room with Bethany.
Beat the Void with Bethany.
Complete the Corpse with Magdalene.
Complete the final chapter with ???.
Complete the Corpse with the Lost.
Complete the Corpse with ???.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Eden.
Complete the Corpse with Isaac.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Complete the final chapter with Eden.
Complete the final chapter with Apollyon.
Complete the final chapter with Lilith.
Complete the Corpse with the Forgotten.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Azazel.
Complete the final chapter with the Forgotten.
Complete the final chapter with Keeper.
The other side is calling...
Complete the Corpse with Keeper.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Kill Hornfel before he escapes!
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Cathedral with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Make a new friend!
Kill 10 Battery Bums.
They will charge you up... for a small fee.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.