Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
New mode unlocked!
Unlocked even more bosses!
Isaac now holds the D6!
Unlocked new bosses!
Unlocked a new character.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new enemies!
You are the best!!
New boss in the womb!
Donated 600 pennies to the shop.
Unlocked Challenge #19.
They are waiting.
You became Lord of the Flies.
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat womb without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
Built him out of meat cubes.
Donated 100 pennies to the shop.
New boss in the caves!
The game just got harder!
New boss in the depths!
Unlocked another miniboss!
Unlocked Challenge #6.
Unlocked Challenge #8.
Beat basement without taking damage.
New boss in the basement!
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Make a new friend!
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
They will charge you up... for a small fee.
Obtain 99 pennies. Then spend every single one of them.
Complete Boss Rush with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with the Lost.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Kids shouldn't believe in fortunes...
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Apollyon.
Complete the final chapter with the Forgotten.
Complete the Corpse with Keeper.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Lilith.
Kill 10 Battery Bums.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Azazel.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Defeat Baby Plum 10 times.
Complete the Corpse with Isaac.
Kill Hornfel before he escapes!
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mausoleum.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete ??? 3 times.