Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked Challenge #11.
Unlocked Challenge #4.
Unlocked a new character.
Unlocked a new co-player baby.
Beat depths without taking damage.
Donated 600 pennies to the shop.
Beat caves without taking damage.
Unlocked Challenge #19.
New mode unlocked!
Unlocked even more bosses!
Unlocked Challenge #8.
New boss in the womb!
Alt stage to the womb.
Unlocked new bosses!
You are the best!!
Unlocked new enemies!
You became Lord of the Flies.
Beat Chest or Dark Room without taking damage.
Built him out of meat cubes.
They are waiting.
Beat womb without taking damage.
Alt stage to the depths.
Alt stage to the caves.
Isaac now holds the D6!
Unlocked a new boss!
New boss in the caves!
New boss in the basement!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
Donated 200 pennies to the shop.
Unlocked Challenge #9.
Unlocked another miniboss!
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked Challenge #26.
Unlocked a secret.
Unlocked Challenge #24.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new challenge.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked super special rocks.
Complete the final chapter with Azazel.
Beat everything in Hard Mode as every character.
Complete the Corpse with Azazel.
Kill 10 Battery Bums.
Complete the Corpse with Apollyon.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Lazarus.
They will charge you up... for a small fee.
Make a new friend!
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Keeper.
Get that song out of her head.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with Keeper.
Complete the Corpse with the Forgotten.
Complete the Corpse with the Lost.
Complete the final chapter with the Forgotten.
Complete the final chapter with ???.
Complete the Corpse with Lilith.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Isaac.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Defeat all bosses in Downpour.
Complete the final chapter with Eden.
Complete the Corpse with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete the final chapter with the Lost.
Complete the final chapter with Lilith.
Complete the final chapter with Apollyon.
Complete the final chapter with Bethany.
Complete the final chapter with Judas.
The other side is calling...
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Beat Greed mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Defeat Baby Plum 10 times.
Kids shouldn't believe in fortunes...
Complete ??? 3 times.
Obtain 99 pennies. Then spend every single one of them.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life