Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat womb without taking damage.
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
Beat depths without taking damage.
You are the best!!
New boss in the womb!
Unlocked Challenge #19.
They are waiting.
You became Lord of the Flies.
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
New boss in the caves!
Unlocked Challenge #9.
Unlocked a new boss!
Unlocked Challenge #8.
Donated 200 pennies to the shop.
The game just got harder!
Beat basement without taking damage.
Beat caves without taking damage.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
New boss in the basement!
Unlocked another miniboss!
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Complete the Corpse with Lilith.
Beat everything in Hard mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with ???.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with Lilith.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Apollyon.
Complete the final chapter with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Eve.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Samson.
Complete the Corpse with Magdalene.
Complete the final chapter with Apollyon.
Make a new friend!
Complete the final chapter with Samson.
Complete the Corpse with Lazarus.
Beat Hard mode as Lazarus without losing a life
Complete the Corpse with Judas.
Complete the final chapter with Magdalene.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with the Lost.
Complete the Corpse with Cain.
Complete the final chapter with Eve.
Complete the final chapter with Cain.
Complete the Corpse with Eden.
Complete the final chapter with ???.
Complete the final chapter with the Lost.
Complete the final chapter with Judas.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Kill 10 Battery Bums.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lazarus.
Defeat Baby Plum 10 times.
Complete the final chapter with Eden.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Complete the Corpse with Azazel.
Where could it lead to?
Get that song out of her head.
Defeat all bosses in the Mines.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Spend 40+ pennies in a single shop.
Complete ??? 3 times.