Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
New boss in the womb!
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new co-player baby.
Beat depths without taking damage.
OMG!
Donated 600 pennies to the shop.
You became Lord of the Flies.
Beat Chest or Dark Room without taking damage.
New boss in the caves!
You are the best!!
Unlocked Challenge #19.
Unlocked a new boss!
They are waiting.
Beat basement without taking damage.
Isaac now holds the D6!
Beat womb without taking damage.
New boss in the basement!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Built him out of meat cubes.
Donated 200 pennies to the shop.
Unlocked Challenge #9.
Unlocked Challenge #8.
New boss in the depths!
The game just got harder!
Unlocked another miniboss!
Beat caves without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Defeat Mega Satan with Jacob and Esau.
They will charge you up... for a small fee.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Keeper.
Complete ??? with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Bethany.
Beat the Void with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lilith.
Complete the final chapter with Eve.
Complete the final chapter with Azazel.
Complete the Corpse with the Lost.
Complete the Corpse with Keeper.
Complete the final chapter with ???.
Complete the Dark Room with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the final chapter with Eden.
Make a new friend!
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Dark Room with Bethany.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Azazel.
Get that song out of her head.
Kids shouldn't believe in fortunes...
Complete the Corpse with Bethany.
Complete the Corpse with ???.
Kill 10 Battery Bums.
Complete the final chapter with the Lost.
Complete the Corpse with Eve.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete Sheol with Jacob and Esau.
Defeat Mega Satan with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Samson.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Spend 40+ pennies in a single shop.
Complete the Corpse with Lazarus.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Defeat Baby Plum 10 times.
Complete the final chapter with Isaac.
Complete the Corpse with Eden.
The other side is calling...
Beat the game in Hard mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Defeat all bosses in the Mausoleum.
Obtain 99 pennies. Then spend every single one of them.
Kill Hornfel before he escapes!
Complete ??? 3 times.