Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
New mode unlocked!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked Challenge #11.
Built him out of meat cubes.
Unlocked Challenge #19.
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
New boss in the womb!
You are the best!!
They are waiting.
Beat womb without taking damage.
Unlocked Challenge #8.
Unlocked another miniboss!
Isaac now holds the D6!
New boss in the caves!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the depths!
New boss in the basement!
Unlocked Challenge #9.
Unlocked a new boss!
You became Lord of the Flies.
Donated 200 pennies to the shop.
The game just got harder!
Beat caves without taking damage.
Beat basement without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Obtain 99 pennies. Then spend every single one of them.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Beat everything in Hard Mode as every character.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the final chapter with Lazarus.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the final chapter with Keeper.
Complete the Corpse with Azazel.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the final chapter with Eve.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Samson.
Complete the final chapter with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Kill 10 Battery Bums.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Make a new friend!
Complete the final chapter with Samson.
Complete the Corpse with Judas.
Complete the final chapter with Eden.
Complete the final chapter with Lilith.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Bethany.
Kill Hornfel before he escapes!
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mines.
Defeat Baby Plum 10 times.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with the Forgotten.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Azazel.
Get that song out of her head.
Complete the final chapter with Isaac.
Spend 40+ pennies in a single shop.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Defeat all bosses in Downpour.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Complete ??? 3 times.