Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
Unlocked Challenge #11.
Unlocked Challenge #4.
Unlocked even more bosses!
Donated 600 pennies to the shop.
Isaac now holds the D6!
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked new bosses!
New mode unlocked!
Built him out of meat cubes.
Unlocked another miniboss!
You are the best!!
Unlocked new enemies!
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #8.
Beat womb without taking damage.
Alt stage to the womb.
Donated 200 pennies to the shop.
New boss in the basement!
New boss in the womb!
New boss in the caves!
You became Lord of the Flies.
Alt stage to the depths.
Unlocked Challenge #19.
Alt stage to the caves.
They are waiting.
New boss in the depths!
Unlocked Challenge #7.
Alt stage to the basement.
Your future's past waits.
Unlocked Challenge #9.
Unlocked a new boss!
Beat basement without taking damage.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Destroy 100 rocks.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked Challenge #26.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #29.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #24.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Beat everything in Hard Mode as every character.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the final chapter with Apollyon.
Complete the final chapter with Lazarus.
They will charge you up... for a small fee.
Complete the Corpse with Lazarus.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Apollyon.
Make a new friend!
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the final chapter with Azazel.
Kids shouldn't believe in fortunes...
Complete the Corpse with Azazel.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Baby Plum 10 times.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill 10 Battery Bums.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Judas.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Judas.
Enter the Corpse...
Kill Hornfel before he escapes!
Complete ??? 3 times.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.