Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Donated 600 pennies to the shop.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Donated 200 pennies to the shop.
Unlocked Challenge #11.
New boss in the womb!
Beat Chest or Dark Room without taking damage.
You are the best!!
Isaac now holds the D6!
New boss in the caves!
Your future's past waits.
Beat caves without taking damage.
Beat depths without taking damage.
Beat womb without taking damage.
Unlocked a new boss!
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
You became Lord of the Flies.
They are waiting.
Built him out of meat cubes.
Unlocked Challenge #19.
New boss in the depths!
The game just got harder!
Unlocked Challenge #8.
Unlocked Challenge #6.
Unlocked another miniboss!
Beat basement without taking damage.
New boss in the basement!
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a new item
Unlocked Challenge #23.
Unlocked a hidden chapter.
Greed just got harder!
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with Samson.
Complete the final chapter with Magdalene.
Complete the Corpse with Samson.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Lilith.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the Corpse with Magdalene.
Complete the Corpse with Lilith.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the Corpse with Eve.
Get that song out of her head.
Kill 10 Battery Bums.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the Corpse with Lazarus.
Complete the Corpse with Apollyon.
Complete the Corpse with Judas.
Complete the final chapter with Azazel.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
They will charge you up... for a small fee.
Defeat Baby Plum 10 times.
Make a new friend!
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Bethany.
Complete Boss Rush with Bethany.
Kids shouldn't believe in fortunes...
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Spend 40+ pennies in a single shop.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Complete ??? 3 times.