Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked Challenge #11.
Unlocked Challenge #4.
Unlocked even more bosses!
Unlocked a new co-player baby.
New mode unlocked!
Unlocked a new character.
New boss in the womb!
Unlocked new bosses!
Alt stage to the womb.
New boss in the basement!
New boss in the caves!
Donated 600 pennies to the shop.
You are the best!!
Unlocked Challenge #19.
Beat Chest or Dark Room without taking damage.
They are waiting.
Unlocked new enemies!
Alt stage to the depths.
Alt stage to the caves.
Built him out of meat cubes.
Isaac now holds the D6!
Unlocked Challenge #8.
Unlocked another miniboss!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
Donated 200 pennies to the shop.
Unlocked Challenge #9.
Unlocked a new boss!
Donated 100 pennies to the shop.
You became Lord of the Flies.
The game just got harder!
Beat womb without taking damage.
Beat depths without taking damage.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Beat caves without taking damage.
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked...
Nerd x 1000000
Unlocked Challenge #24.
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a new item
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Get that song out of her head.
They will charge you up... for a small fee.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the final chapter with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with the Lost.
Kill 10 Battery Bums.
Complete the Corpse with Samson.
Complete Sheol with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Lost.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with the Forgotten.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Bethany.
Make a new friend!
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Defeat all bosses in Downpour.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Defeat all bosses in the Mines.
Complete the Corpse with Magdalene.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the final chapter with Cain.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Defeat all bosses in the Mausoleum.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Apollyon.
The other side is calling...
Defeat Baby Plum 10 times.
You are just like your father...
Complete the Corpse with Lilith.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Spend 40+ pennies in a single shop.
Complete ??? 3 times.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...