Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Unlocked even more bosses!
Unlocked a new co-player baby.
Unlocked Challenge #4.
Unlocked new bosses!
Unlocked Challenge #11.
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
New mode unlocked!
Unlocked a new character.
Alt stage to the womb.
You are the best!!
Alt stage to the depths.
Unlocked Challenge #19.
Donated 600 pennies to the shop.
New boss in the basement!
New boss in the caves!
Alt stage to the caves.
They are waiting.
Unlocked new enemies!
You became Lord of the Flies.
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
Unlocked Challenge #9.
Unlocked a new boss!
Beat caves without taking damage.
The game just got harder!
Donated 200 pennies to the shop.
Built him out of meat cubes.
Unlocked another miniboss!
Beat womb without taking damage.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked Challenge #8.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked Challenge #24.
Nerd x 1000000
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked Challenge #29.
Unlocked a hidden chapter.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked a new challenge.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked super special rocks.
They will charge you up... for a small fee.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Beat everything in Hard Mode as every character.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the Corpse with Samson.
Beat Greedier mode with Bethany.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Kill 10 Battery Bums.
Get that song out of her head.
Complete the final chapter with Apollyon.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the final chapter with Samson.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Make a new friend!
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Defeat Baby Plum 10 times.
Complete the Corpse with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Lost.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Beat Greed mode with Bethany.
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.