Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Unlocked a new co-player baby.
New mode unlocked!
Unlocked Challenge #4.
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #8.
Built him out of meat cubes.
Beat womb without taking damage.
You are the best!!
Unlocked new enemies!
Beat depths without taking damage.
Unlocked even more bosses!
New boss in the womb!
Unlocked Challenge #19.
Unlocked new bosses!
Alt stage to the womb.
They are waiting.
Isaac now holds the D6!
Alt stage to the depths.
Alt stage to the caves.
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
Beat caves without taking damage.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
New boss in the basement!
New boss in the caves!
Beat basement without taking damage.
Unlocked a new boss!
Destroy 100 rocks.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #6.
Unlocked Challenge #10.
Unlocked Challenge #20.
You became Lord of the Flies.
The game just got harder!
New boss in the depths!
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Nerd x 1000000
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #24.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Keeper.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Keeper.
Complete the Corpse with Bethany.
Beat the Void with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with ???.
Complete the Corpse with ???.
Make a new friend!
Complete the Corpse with Apollyon.
Complete the final chapter with Eve.
They will charge you up... for a small fee.
Complete the Corpse with Eve.
Complete the final chapter with Apollyon.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Magdalene.
Complete the final chapter with Lazarus.
Complete the Corpse with Lilith.
Complete the Corpse with Cain.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the Corpse with Judas.
Obtain 99 pennies. Then spend every single one of them.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Kill 10 Battery Bums.
Complete the final chapter with Magdalene.
Complete the final chapter with Lilith.
Complete the final chapter with Cain.
Complete the final chapter with Eden.
Complete the final chapter with Samson.
Complete the Corpse with Eden.
Complete the final chapter with Judas.
Complete the Corpse with the Forgotten.
Kids shouldn't believe in fortunes...
Complete the final chapter with the Forgotten.
Complete the final chapter with Azazel.
The other side is calling...
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Get that song out of her head.
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Complete the Dark Room with Bethany.
Complete the Chest with Bethany.
Defeat Mega Satan with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat the game in Hard mode with Bethany.
Spend 40+ pennies in a single shop.
Complete Sheol with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.