Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
Unlocked a new item.
OMG!
Unlocked a new co-player baby.
Unlocked Challenge #4.
Built him out of meat cubes.
Unlocked even more bosses!
Unlocked Challenge #8.
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
New mode unlocked!
Unlocked a new character.
Unlocked new bosses!
New boss in the womb!
You are the best!!
Unlocked new enemies!
Unlocked Challenge #19.
Beat basement without taking damage.
They are waiting.
Beat caves without taking damage.
Donated 600 pennies to the shop.
Alt stage to the womb.
Alt stage to the depths.
New boss in the caves!
Alt stage to the caves.
New boss in the basement!
Unlocked another miniboss!
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
You became Lord of the Flies.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
The game just got harder!
Unlocked a new boss!
Unlocked Challenge #6.
Beat womb without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat depths without taking damage.
Donated 100 pennies to the shop.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked Challenge #24.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
They will charge you up... for a small fee.
Defeat Mega Satan with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Void with Jacob and Esau.
Complete the Corpse with Eve.
Complete the Corpse with Apollyon.
Beat Greed mode with Bethany.
Complete the final chapter with Cain.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the Corpse with Cain.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Lilith.
Complete the final chapter with Lazarus.
Complete the Corpse with Magdalene.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with Lazarus.
Complete the final chapter with Judas.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Isaac.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with Magdalene.
Complete the Corpse with Eden.
Complete the final chapter with ???.
Complete the final chapter with Apollyon.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Kill 10 Battery Bums.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the final chapter with Lilith.
Complete the Corpse with Bethany.
Defeat all bosses in the Mines.
Make a new friend!
Obtain 99 pennies. Then spend every single one of them.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Kids shouldn't believe in fortunes...
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with the Forgotten.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Defeat Baby Plum 10 times.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.