Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
Unlocked even more bosses!
Unlocked a new co-player baby.
Alt stage to the womb.
Unlocked new bosses!
New boss in the womb!
Alt stage to the depths.
You are the best!!
Unlocked a new character.
Beat caves without taking damage.
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Beat depths without taking damage.
Beat basement without taking damage.
Alt stage to the caves.
Donated 600 pennies to the shop.
Isaac now holds the D6!
New boss in the caves!
Unlocked Challenge #11.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
New boss in the depths!
Built him out of meat cubes.
Unlocked Challenge #9.
New mode unlocked!
Unlocked a new boss!
You became Lord of the Flies.
They are waiting.
Unlocked new enemies!
The game just got harder!
New boss in the basement!
Unlocked another miniboss!
Donated 200 pennies to the shop.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #5.
Unlocked Challenge #8.
Unlocked Challenge #10.
Unlocked Challenge #20.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked...
Unlocked a new starting item.
Unlocked Challenge #24.
Nerd x 1000000
Unlocked a new item
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with the Forgotten.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Keeper.
Complete the final chapter with Eden.
Complete the Corpse with Apollyon.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Eden.
Get that song out of her head.
Complete the final chapter with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with ???.
Obtain 99 pennies. Then spend every single one of them.
Make a new friend!
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat Baby Plum 10 times.
Complete the Chest with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat all bosses in the Mausoleum.
Defeat Mega Satan with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.
Defeat all bosses in Downpour.
Complete ??? 3 times.