Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat womb without taking damage.
Beat depths without taking damage.
Unlocked Challenge #11.
New boss in the womb!
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
You are the best!!
You became Lord of the Flies.
Isaac now holds the D6!
Unlocked Challenge #19.
They are waiting.
Unlocked Challenge #8.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked another miniboss!
Unlocked Challenge #9.
New boss in the depths!
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the basement!
Unlocked a new boss!
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat caves without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Kids shouldn't believe in fortunes...
Obtain 99 pennies. Then spend every single one of them.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with Eden.
Complete Boss Rush with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lilith.
Complete the final chapter with Keeper.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Make a new friend!
Complete the final chapter with Apollyon.
Complete the final chapter with Lazarus.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with the Forgotten.
Complete the Corpse with the Lost.
Complete the Corpse with Bethany.
Complete the final chapter with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the Corpse with Judas.
Defeat Baby Plum 10 times.
Complete the Corpse with Apollyon.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Defeat Mega Satan with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
The other side is calling...
You are just like your father...
Complete the Corpse with Lazarus.
Where could it lead to?
Enter the Corpse...
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Cathedral with Bethany.
Complete the Chest with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.