Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
New mode unlocked!
Donated 600 pennies to the shop.
Unlocked even more bosses!
You became Lord of the Flies.
You are the best!!
Unlocked new enemies!
New boss in the womb!
Beat womb without taking damage.
Unlocked new bosses!
Unlocked Challenge #11.
Unlocked Challenge #19.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
They are waiting.
Beat caves without taking damage.
Unlocked Challenge #8.
Isaac now holds the D6!
Built him out of meat cubes.
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 200 pennies to the shop.
Unlocked Challenge #9.
New boss in the caves!
Donated 100 pennies to the shop.
New boss in the depths!
The game just got harder!
Beat depths without taking damage.
New boss in the basement!
Unlocked Challenge #6.
Unlocked another miniboss!
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Unlocked Challenge #24.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a new item
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked super special rocks.
Unlocked a new area.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete ??? with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Kill 10 Battery Bums.
The other side is calling...
You are just like your father...
Complete the Corpse with ???.
Where could it lead to?
Beat Greedier mode with Bethany.
Make a new friend!
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Defeat all bosses in Downpour.
Get that song out of her head.
Kill Hornfel before he escapes!
Defeat all bosses in the Mines.
Complete ??? 3 times.
Beat Greed mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.