Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat womb without taking damage.
New mode unlocked!
Unlocked even more bosses!
Beat depths without taking damage.
Donated 600 pennies to the shop.
Unlocked another miniboss!
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
Isaac now holds the D6!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked Challenge #11.
New boss in the womb!
Beat caves without taking damage.
Donated 200 pennies to the shop.
Unlocked Challenge #19.
Donated 100 pennies to the shop.
You are the best!!
Unlocked Challenge #8.
You became Lord of the Flies.
They are waiting.
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the caves!
Unlocked Challenge #9.
New boss in the depths!
New boss in the basement!
The game just got harder!
Donated 20 pennies to the shop.
Unlocked Challenge #6.
Destroy 100 rocks.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Apollyon.
Complete the Void with Jacob and Esau.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the Corpse with the Lost.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Keeper.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Samson.
Complete the final chapter with the Lost.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Judas.
Complete the final chapter with Keeper.
Complete the Corpse with Samson.
Complete the final chapter with the Forgotten.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with the Forgotten.
Complete the Corpse with Lazarus.
Complete the Corpse with Magdalene.
Complete the Corpse with Lilith.
Complete the Corpse with Eden.
Complete the final chapter with Magdalene.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Cain.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Lilith.
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Make a new friend!
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Enter the Corpse...
Get that song out of her head.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.